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Lower urinary tract nerve responses to high-density epidural spinal cord stimulation in cats

Maria Jantz
,
Chaitanya Gopinath
,
Ritesh Kumar
,
Robert Gaunt
,
Bryan McLaughlin

During epidural electrical spinal cord stimulation at the sacral cord and cauda equina, compound action potentials were recorded from nerve cuffs on the pelvic nerve as well as the pudendal nerve and its branches.

Updated on November 4, 2022 (Version 1)

Corresponding Contributor:

Robert Gaunt
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Dataset Overview

Study Purpose: Bladder dysfunction following spinal cord injury has a substantial impact on quality of life. Epidural spinal cord stimulators are already regularly implanted to treat back pain, meaning that they are a rapidly translatable method if they could be used to treat loss of bladder control. Here, we demonstrate that localized electrical stimulation through an epidural array can selectively recruit lower urinary tract (LUT) afferents, thereby activating specific reflexes modulating bladder function.

Data Collection: In anesthetized cats, we placed a high-density 16-channel epidural array at several locations above the sacral spinal cord and cauda equina. We implanted nerve cuffs on the pelvic nerve, branches of the pudendal nerve, and on the sciatic nerve to record the antidromic action potentials evoked by stimulation of the spinal cord.

Data Conclusion: Ultimately, we were able to selectively recruit targeted bladder afferents and observed that this recruitment also modulated physiological parameters. We believe that being able to control the activity of bladder afferent pathways could be used to systematically modify the function in the LUT.


Curator's Notes

Experimental Design: Animals were anesthetized and nerve cuffs were placed on the sciatic nerve, pelvic nerve, pudendal nerve, and the sensory, deep perineal, and caudal rectal branches of the pudendal nerve. Each animal was then given a laminectomy and an epidural spinal cord array was placed on the dorsal surface of the spinal cord. Spinal cord stimulation was applied in stimulation trains, typically 300 pulses in length at varying frequencies, and nerve responses were recorded.

Completeness: Complete.

Subjects & Samples: This dataset contains experimental data from 8 male cats and 1 female cat ranging in age from ~9 months and ~9 years old. All subjects are designated as being in the "experimental" group.

Primary vs derivative data: In the primary folder, data is split by subject and then run number. Results are in .xlsx files. A detailed description of each file type and internal headers is provided in a README file. There is no derivative data folder.

Important Notes: This dataset is a replacement for the dataset https://doi.org/10.26275/zupz-yhtf that was retracted by the authors due to corrupted files in the initial upload. The dataset was not usable in its previous form and was replaced with the current version.

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Publishing history

November 4, 2022
Originally Published
November 4, 2022 (Version 1)
Last Updated

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