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Code and computational model associated with the Fecobionics device studies.

Single neurons were mapped and cardiac anatomy was annotated in image volumes of male and female rat hearts to compare the intrinsic cardiac nervous system between individuals and across sexes.

Computational models and resulting activation thresholds of vagus nerve stimulation for simplified nerve morphologies, built with ASCENT v1.0.3. Modeled electrode designs include monopolar and clinical LivaNova helical cuffs.

Computational models and resulting activation thresholds of vagus nerve stimulation with the LivaNova helical cuff, built with ASCENT v1.1.1, using histology from nine human vagus nerves at the mid-cervical level.

Network model of parasympathetic innervation of the sinoatrial node.

Contractile response to the chemogenetic activation or inhibition of distinct myenteric neuronal subsets

Methodology of neural recordings using array electrodes. How to analyze for signal to noise, spike sorting, and higher-level analysis.

Model of motor unit activation in laryngeal muscles.

Simulation and viewer for a model of autonomic control of cardiac function contributed by Prof. Guy Kember from Dalhousie University.

The generated body scaffold was fitted to data, and the organ fiducial markers were embedded in the human whole-body. The landmarks were obtained from image data and also were defined in the body scaffold. Furthermore, nerve centrelines are added.

Computational model of vagus nerve stimulation in mice with a bipolar cuff electrode, built with ASCENT v1.1.4, using a generalized nerve morphology.

Computational models of monopolar pig vagus nerve stimulation with a six-contact cuff, built with ASCENT v1.0.1, using the histology for six pigs in which electrophysiological outputs were recorded in vivo.

A wired, active UroMOCA device was placed in the subject's bladder. The device was tested for its ability to transmit bladder pressure, conductivity, and conductance data from the device to a computer.

Testing of wired bowel sensor devices

Fixed samples of human atria and ventricles were sectioned and immunostained for neural markers using the ABC method. Specific targets were tyrosine hydroxylase, vesicular ACh transporter, and PGP9.5. Regional nerve densities were quantified using ImageJ.

This dataset includes GCaMP calcium imaging of myenteric neurons in the mouse proximal colon during spontaneous colon motor complexes (CMCs). Data were used in Nestor-Kalinoski et al, 2022: https://doi.org/10.1016/j.jcmgh.2021.08.016

GCaMP recordings from thoracolumbar (T12 to L2) and lumbosacral (L5 to S1) DRG in responses to two chemical stimuli to the attached colorectum, i.e., acidic hypertonic solution (AHS) and inflammatory soup (IS).

Distributions of enteroendocrine cells (EEC), defined by the hormones they contain within the human fundus and corpus are mapped onto the human stomach scaffold.

This dataset contains the effects of abdominal vagus nerve stimulation on nodose ganglion cell activity recorded from multi-electrode arrays and gastrointestinal myoelectric responses recorded with serosal surface electrodes in the ferret.

Current clamp recordings of action potential responses to norepinephrine, neuropeptide Y, acetylcholine, and vasoactive intestinal peptide.

Mapping of the vagal afferent innervation of the mouse lung using a combination of viral and genetic approaches to label unique vagal sensory subsets innervating the lung

Spatial distribution and morphometric characterization of mucosal afferents associated with the pylorus, antrum and corpus of the rat stomach

Immunohistochemical analysis of the relationship between enteroendocrine cells and nerve endings in the gastric mucosa of human and pig. The innervation of mucosal vasculature is also revealed and current knowledge of the gastric innervation summarized.

Immunohistochemical validation of mouse genetic strategies used to specifically activate and silence enterochromaffin cells in the intestine

Effect of electrical stimulation of the vagus nerve on colonic contractions and colonic neuron/ICC calcium activity, in ex vivo preparations lacking the targets of vagal afferent input.