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Computational-based mechanical analysis of Fecobionics data

Code and computational model associated with the Fecobionics device studies.
16 Files
36.89 MB
No Records
CC-BY-4.0
Bhavesh Patel updated on March 22, 2023
force, model, defecation
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Comparison of the intrinsic cardiac nervous system across male and female rat hearts

Single neurons were mapped and cardiac anatomy was annotated in image volumes of male and female rat hearts to compare the intrinsic cardiac nervous system between individuals and across sexes.
92 Files
439.81 GB
50 Records
CC-BY-4.0

Sponsored by

NIH SPARC Program

Zixi Cheng updated on March 22, 2023
rat intrinsic cardiac neurons, 3d heart reconstructions, rodent cardiac anatomy + More
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Population of mock morphological models of vagus nerve stimulation with cuff electrodes for the purpose of studying the effect of fascicle diameter on activation threshold

Computational models and resulting activation thresholds of vagus nerve stimulation for simplified nerve morphologies, built with ASCENT v1.0.3. Modeled electrode designs include monopolar and clinical LivaNova helical cuffs.
23,401 Files
676.03 MB
No Records
CC-BY-4.0
Nicole Pelot updated on March 13, 2023
peripheral nerve stimulation, fascicle size, vagus nerve stimulation + More
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Histology-based computational models of implanted human cervical vagus nerve stimulation with the LivaNova helical cuff electrode

Computational models and resulting activation thresholds of vagus nerve stimulation with the LivaNova helical cuff, built with ASCENT v1.1.1, using histology from nine human vagus nerves at the mid-cervical level.
1,093 Files
655.22 MB
No Records
CC-BY-4.0
Eric Musselman updated on March 10, 2023
vagus nerve stimulation, peripheral nerve stimulation, computational modeling + More
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Computational model of heart rate modulation in mice during vagus nerve stimulation

Network model of parasympathetic innervation of the sinoatrial node.
2,674 Files
2.32 TB
No Records
CC-BY-4.0
Nicole Pelot updated on March 8, 2023
sinoatrial node, vagus nerve stimulation, mouse model
Dataset Banner Image

Chemogenetic activation or inhibition of cholinergic or nitrergic myenteric neurons of mouse colon

Contractile response to the chemogenetic activation or inhibition of distinct myenteric neuronal subsets
121 Files
2.04 GB
38 Records
CC-BY-4.0

Sponsored by

NIH SPARC Program

Thomas Gould updated on March 2, 2023
cholinergic, myenteric plexus, nitrergic + More
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Cardioneural recordings using floating multi-channel plunge micro-electrodes in pigs

Methodology of neural recordings using array electrodes. How to analyze for signal to noise, spike sorting, and higher-level analysis.
67 Files
1.64 GB
47 Records
CC-BY-4.0

Sponsored by

NIH SPARC Program

Jeffrey Ardell updated on March 2, 2023
nodose ganglion, microarray, pig + More
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Computational model of laryngeal muscle activation in mice during vagus nerve stimulation

Model of motor unit activation in laryngeal muscles.
91 Files
34.99 GB
No Records
CC-BY-4.0
Nicole Pelot updated on March 9, 2023
vagus nerve stimulation, muscle activation, side effects + More
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Kember Cardiac Nerve Model

Simulation and viewer for a model of autonomic control of cardiac function contributed by Prof. Guy Kember from Dalhousie University.
10 Files
86.14 KB
No Records
CC-BY-4.0
Elisabetta Iavarone updated on March 1, 2023
heart, myocardial infarction, autonomic
Dataset Banner Image

A 3D human whole-body model with integrated organs vasculature musculoskeletal and nervous systems for mapping nerves

The generated body scaffold was fitted to data, and the organ fiducial markers were embedded in the human whole-body. The landmarks were obtained from image data and also were defined in the body scaffold. Furthermore, nerve centrelines are added.
308 Files
116.91 MB
No Records
CC-BY-4.0
Elias Soltani updated on February 28, 2023
musculoskeletal system, vasculature system, nervous system + More
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Computational model of vagus nerve stimulation in mice with bipolar cuff electrode

Computational model of vagus nerve stimulation in mice with a bipolar cuff electrode, built with ASCENT v1.1.4, using a generalized nerve morphology.
3,888 Files
106.37 MB
No Records
CC-BY-4.0
Eric Musselman updated on March 9, 2023
vagus nerve, computational modeling, vagus nerve stimulation + More
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Pig-specific computational models of monopolar vagus nerve stimulation with a six-contact cuff electrode

Computational models of monopolar pig vagus nerve stimulation with a six-contact cuff, built with ASCENT v1.0.1, using the histology for six pigs in which electrophysiological outputs were recorded in vivo.
6,419 Files
442.74 MB
19 Records
CC-BY-4.0
Eric Musselman updated on March 9, 2023
vagus nerve, computational modeling, vagus nerve stimulation + More
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Acute wired Urological Monitor of Conscious Activity (UroMOCA) implantation in feline bladder

A wired, active UroMOCA device was placed in the subject's bladder. The device was tested for its ability to transmit bladder pressure, conductivity, and conductance data from the device to a computer.
868 Files
1.31 GB
23 Records
CC-BY-4.0

Sponsored by

NIH SPARC Program

Margot Damaser updated on February 2, 2023
wireless, uromoca, cat + More
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Acute Wired Colonic Monitor of Conscious Activity (ColoMOCA) implantation in pig bowel

Testing of wired bowel sensor devices
119 Files
15.15 MB
24 Records
CC-BY-4.0

Sponsored by

NIH SPARC Program

Margot Damaser updated on February 2, 2023
colomoca, wireless, pig + More
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Regional analysis of autonomic nerves in normal and diseased human hearts

Fixed samples of human atria and ventricles were sectioned and immunostained for neural markers using the ABC method. Specific targets were tyrosine hydroxylase, vesicular ACh transporter, and PGP9.5. Regional nerve densities were quantified using ImageJ.
7,866 Files
22.41 GB
107 Records
CC-BY-4.0
Donald Hoover updated on January 19, 2023
heart, neurocardiology
Dataset Banner Image

Myenteric neuron activity during spontaneous motor complexes in mouse colon

This dataset includes GCaMP calcium imaging of myenteric neurons in the mouse proximal colon during spontaneous colon motor complexes (CMCs). Data were used in Nestor-Kalinoski et al, 2022: https://doi.org/10.1016/j.jcmgh.2021.08.016
26 Files
6.09 GB
14 Records
CC-BY-4.0
Kristen Smith-Edwards updated on January 12, 2023
colon motor complex, mus sp., calcium imaging + More
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Calcium imaging of mouse dorsal root ganglion (DRG) neurons in response to chemical stimuli of distal colon and rectum (colorectum)

GCaMP recordings from thoracolumbar (T12 to L2) and lumbosacral (L5 to S1) DRG in responses to two chemical stimuli to the attached colorectum, i.e., acidic hypertonic solution (AHS) and inflammatory soup (IS).
5,141 Files
1.7 TB
87 Records
CDLA-Permissive-1.0
Bin Feng updated on January 12, 2023
rectum, drg, single-fiber + More
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Scaffold map - Mapping of human gastric enteroendocrine cells

Distributions of enteroendocrine cells (EEC), defined by the hormones they contain within the human fundus and corpus are mapped onto the human stomach scaffold.
71 Files
28.4 MB
7 Records
CC-BY-4.0
Mabelle Lin updated on January 11, 2023
human, cell density, cell distribution + More
Dataset Banner Image

Selective stimulation of the ferret abdominal vagus nerve with multi‐contact nerve cuff electrodes

This dataset contains the effects of abdominal vagus nerve stimulation on nodose ganglion cell activity recorded from multi-electrode arrays and gastrointestinal myoelectric responses recorded with serosal surface electrodes in the ferret.
2,775 Files
200.34 GB
34 Records
CC-BY-4.0
Charles Horn updated on January 10, 2023
stomach, intestine, gastrointestinal + More
Dataset Banner Image

Sympathetic and parasympathetic effects on action potentials in isolated pig ventricular myocytes

Current clamp recordings of action potential responses to norepinephrine, neuropeptide Y, acetylcholine, and vasoactive intestinal peptide.
124 Files
2.04 GB
153 Records
ODC-BY
Robert Harvey updated on January 7, 2023
neuropeptide y, vasoactive intestinal peptide, norepinephrine + More
Dataset Banner Image

Mapping of the vagal afferent innervation of the mouse lung

Mapping of the vagal afferent innervation of the mouse lung using a combination of viral and genetic approaches to label unique vagal sensory subsets innervating the lung
172 Files
1.65 TB
30 Records
CC-BY-4.0
Thomas Taylor-Clark updated on January 10, 2023
bronchi, nodose, nerve terminals + More
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Spatial distribution and morphometric characterization of mucosal afferents of the pylorus of the rat stomach

Spatial distribution and morphometric characterization of mucosal afferents associated with the pylorus, antrum and corpus of the rat stomach
54 Files
132.59 MB
215 Records
CC-BY-4.0
Deborah Jaffey updated on February 13, 2023
vagal afferent, pylorus, mucosa
Dataset Banner Image

Innervation of enteroendocrine cells in the gastric mucosa in human and pig - including a description of the innervation of mucosal vasculature

Immunohistochemical analysis of the relationship between enteroendocrine cells and nerve endings in the gastric mucosa of human and pig. The innervation of mucosal vasculature is also revealed and current knowledge of the gastric innervation summarized.
127 Files
43.46 GB
38 Records
CC-BY-4.0
Martin Stebbing updated on January 6, 2023
ghrelin, human, vip + More
Dataset Banner Image

Mouse genetic models to manipulate enterochromaffin cell activity

Immunohistochemical validation of mouse genetic strategies used to specifically activate and silence enterochromaffin cells in the intestine
72 Files
93.66 GB
28 Records
CC-BY-4.0
Dataset will be released on October 6, 2023
serotonin, intestine, immunohistochemistry + More
Dataset Banner Image

Calcium imaging and tension recording in response to stimulation of the vagus nerve (VNS)

Effect of electrical stimulation of the vagus nerve on colonic contractions and colonic neuron/ICC calcium activity, in ex vivo preparations lacking the targets of vagal afferent input.
44 Files
38.9 GB
48 Records
CC-BY-4.0
Thomas Gould updated on January 3, 2023
calcium imaging, vagus nerve stimulation, colon + More
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