Find and access public scientific datasets.

We are developing a novel wireless device named Fecobionics for mapping colonic and anorectal neuromuscular function. The current dataset contains results from the Fecobionics test in the anorectal of human subjects with fecal incontinence.

The generated body scaffold was fitted to data, and the organ fiducial markers were embedded in the human whole-body. The landmarks were obtained from image data and also were defined in the body scaffold. Furthermore, nerve centrelines are added.

A digital twin for predicting neuromodulation

Stellate ganglia of 15-16 week old Wistar and Spontaneously Hypertensive Rats were analyzed by: RNA-sequencing, differential analysis, and gene ontology analysis. Data were analyzed by a pipeline consisting of Salmon, DESeq2, and clusterprofiler.

Describes regional differences in gastric wall structure and in the types and densities of hormone secreting cells in the pig stomach.

MicroCT imaging of the human cervical vagus nerve: slices at 0.5 cm spacing are provided across a 5 cm window representing the surgical window typical of vagus nerve stimulation. Derived data include fascicle morphometry, splitting and merging events.

A computational workflow for integration and implementation of a reusable and reproducible human cardiac multi-scale electrophysiology model. Caption: Illustration of ion channels and action potential propogation in cardiac tissue

Tutorial developed during the SPARC Fair Codeathon 2022

A computational workflow for integration and implementation of a reusable and reproducible rabbit cardiac multi-scale electrophysiology model. Caption: Illustration of ion channels and action potential propogation in cardiac tissue.

Trichrome stained histology of the pig cervical vagus nerve at the region of vagus nerve stimulation (VNS).

A carbon nanotube yarn (CNTY) biosensor was used to chronically record from the vagus nerves of freely moving rats for over 40 continuous hours.

Visceromotor responses (VMR) to colorectal distension (CRD) measured by EMG recordings from electrodes implanted in the abdominal musculature.

Anatomical mapping of sympathetic efferent projection to the mouse heart

Code and computational model associated with the Fecobionics device studies.

Single neurons were mapped and cardiac anatomy was annotated in image volumes of male and female rat hearts to compare the intrinsic cardiac nervous system between individuals and across sexes.

Computational models and resulting activation thresholds of vagus nerve stimulation for simplified nerve morphologies, built with ASCENT v1.0.3. Modeled electrode designs include monopolar and clinical LivaNova helical cuffs.

Computational models and resulting activation thresholds of vagus nerve stimulation with the LivaNova helical cuff, built with ASCENT v1.1.1, using histology from nine human vagus nerves at the mid-cervical level.

Network model of parasympathetic innervation of the sinoatrial node.

Contractile response to the chemogenetic activation or inhibition of distinct myenteric neuronal subsets

Methodology of neural recordings using array electrodes. How to analyze for signal to noise, spike sorting, and higher-level analysis.

Model of motor unit activation in laryngeal muscles.

Simulation and viewer for a model of autonomic control of cardiac function contributed by Prof. Guy Kember from Dalhousie University.

Computational model of vagus nerve stimulation in mice with a bipolar cuff electrode, built with ASCENT v1.1.4, using a generalized nerve morphology.

Computational models of monopolar pig vagus nerve stimulation with a six-contact cuff, built with ASCENT v1.0.1, using the histology for six pigs in which electrophysiological outputs were recorded in vivo.

A wired, active UroMOCA device was placed in the subject's bladder. The device was tested for its ability to transmit bladder pressure, conductivity, and conductance data from the device to a computer.