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Fernando Ivich updated on September 30, 2023
ratiometric, diffuse fluorescence, optical sensors
Dataset Banner Image

Mid-lumbar (L3) epidural stimulation effects on bladder and external urethral sphincter in non-injured and chronically transected urethane-anesthetized rats

In the current pre-clinical study, the L3 was targeted with scES to examine whether the EUS could be modulated under intact and chronic complete SCI conditions.
27 Files
17.8 GB
No Records
CC-BY-4.0
Daniel Medina Aguinaga updated on September 29, 2023
bladder, spinal cord injury, epidural stimulation + More
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MicroCT imaging of the fascicular structure in the porcine right and left cervical vagus nerve

This dataset provides a collection of microCT scans of the left and right vagus nerves from domestic pigs. Scans were captured, spanning a 15-20 cm window from the nodose ganglion to the superior cardiac branch, with a precision of 20 um slice intervals.
24 Files
51.29 GB
No Records
CC-BY-4.0
Max Haberbusch updated on September 29, 2023
vagus nerve, superior cardiac branch, fascicular anatomy + More
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Calcium imaging tension recording and pellet transit in mouse colon in response to stimulation of the pelvic nerve (PNS)

Effect of electrical stimulation of the vagus nerve on colonic contractions, colonic pellet transit, and colonic neuron/ICC calcium activity
51 Files
44.89 GB
No Records
CC-BY-4.0
Thomas Gould updated on September 29, 2023
pelvic nerve stimulation, colonic motility, calciumimaging
Dataset Banner Image

Cardiovascular system model for comprehending the acute cardiac effects of vagus nerve stimulation

This model represents an evolved iteration of the original Simulink model that emulates the acute cardiac outcomes resulting from vagus nerve stimulation, as initially proposed by Haberbusch et al (see associated publications)
9 Files
85.93 KB
No Records
MIT
Elisabetta Iavarone updated on September 29, 2023
heart, vagus nerve stimulation, circulation + More
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Optogenetic activation of nitrergic and cholinergic neurons of murine colonic myenteric plexus

Tension recordings of proximal, middle and distal colon after optogenetic activation of nitrergic and cholinergic myenteric neurons
72 Files
1.59 GB
41 Records
CC-BY-4.0

Sponsored by

NIH SPARC Program

Thomas Gould updated on September 8, 2023
cholinergic, myenteric plexus, nitrergic + More
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QuiltedTutorials 1 – Mapping 2D Data to 3D Organ Scaffold

This tutorials shows how to project 2D anatomical data to 3D organ scaffolds available on the SPARC Portal
10 Files
50.19 KB
No Records
LGPL-3.0
Elisabetta Iavarone updated on August 31, 2023
scaffold, stomach, tutorial + More
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Stimulation of the pig vagus nerve to modulate target effect versus side effect

This dataset contains the electroneurography, electromyography, and histology of pig vagus nerve, following vagus nerve stimulation with the ImThera stimulating cuff.
4,068 Files
250.86 GB
16 Records
CC-BY-4.0
Stephan Blanz updated on August 25, 2023
vagus nerve, vagus nerve stimulation, vns + More
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Scaffold map - Quantification of rat gastric enteroendocrine cells

Distributions of enteroendocrine cells (EEC), defined by the hormones they contain within the rat corpus and antrum are mapped onto the rat stomach scaffold.
94 Files
39.98 MB
11 Records
CC-BY-4.0
Mabelle Lin updated on August 25, 2023
rat, cell density, cell distribution + More
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Antibodies tested in the colon – Human

List of antibodies that were tested in the human colon.
487 Files
1.33 GB
169 Records
CC-BY-4.0
Simon Brookes updated on August 25, 2023
immunochemistry, human, clarity + More
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Targets of sympathetic nerves in myenteric plexus of human colon

Sympathetic endings on human colonic myenteric neurons
300 Files
113.19 GB
28 Records
CC-BY-4.0
Simon Brookes updated on August 25, 2023
myenteric, colon, cholinergic + More
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CLARITY and 3D imaging with high resolution and deep scanning of innervation in the pig colon by using SP8 DIVE fully tunable spectral multiphoton microscope

Deep scanning of innervation in the pig colon by using SP8 DIVE multiphoton microscope
136 Files
136.87 GB
18 Records
CC-BY-4.0
Pu-Qing Yuan updated on August 18, 2023
sp8 dive multiphoton microscope, pig colon, innervation + More
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Ussing chamber experiments for distension evoked secretion in human colon

Distention evoked secretion in human colon
881 Files
913.08 MB
533 Records
CC-BY-4.0
Klaus Michel updated on August 18, 2023
enteric nervous system, mechanosensitivity, human + More
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Effect of chronic gastric electrical stimulation on the feeding behavior of diet-induced obese male Sprague-Dawley rats consuming a 45% high-fat diet

Microstructural analysis of food intake as a behavioral endpoint to determine the effect of chronic gastric electrical stimulation on the consumption of a 45% high-fat diet by diet-induced obese male Sprague-Dawley rats
58 Files
2.96 MB
25 Records
CC-BY-4.0
Robert Phillips updated on August 18, 2023
male, neuromodulation, rat + More
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High resolution manometry

Organ bath studies of motility recorded from entire sections surgically excised human colon.
162 Files
407.89 MB
92 Records
CC-BY-4.0

Sponsored by

NIH SPARC Program

Phil Dinning updated on August 18, 2023
colon, contractions, manometry + More
Dataset Banner Image

Scaffold map - Mapping of human gastric enteroendocrine cells

Distributions of enteroendocrine cells (EEC), defined by the hormones they contain within the human fundus and corpus are mapped onto the human stomach scaffold.
70 Files
28.4 MB
10 Records
CC-BY-4.0
Mabelle Lin updated on July 21, 2023
human, cell density, cell distribution + More
Dataset Banner Image

Scaffold map - Quantitative analysis of enteric neurons containing choline acetyltransferase and nitric oxide synthase immunoreactivities in the submucosal and myenteric plexuses of the porcine colon

Choline acetyltransferase and nitric oxide synthase immunoreactivities in the inner submucosal plexus of the ascending porcine colon are mapped onto the pig colon scaffold.
68 Files
425.26 MB
10 Records
CC-BY-4.0
Mabelle Lin updated on July 21, 2023
porcine, colon, enteric neurons
Dataset Banner Image

Influence of acute celiac branch of abdominal vagus nerve stimulation on colonic motility in anesthetized male Yucatan minipigs

Acute celiac branch of vagus nerve electrical stimulation; monitor colon manometry in all regions (proximal, transverse and distal) before, during and post stimulation.
251 Files
1.68 GB
56 Records
CC-BY-4.0

Sponsored by

NIH SPARC Program

Muriel Larauche updated on July 21, 2023
pre-clinical, pelvic, electroceutical-therapy + More
Dataset Banner Image

Influence of acute thoracolumbar root nerves electrical stimulation on colonic motility in anesthetized male Yucatan minipigs

Acute thoracolumbar nerve electrical stimulation; monitor colon manometry in all regions (proximal, transverse and distal) before, during and post stimulation.
96 Files
210.84 MB
29 Records
CC-BY-4.0

Sponsored by

NIH SPARC Program

Muriel Larauche updated on July 20, 2023
gastrointestinal, pelvic, pre-clinical + More
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Influence of direct colon tissue electrical stimulation on colonic motility in anesthetized male Yucatan minipig

Direct proximal colon, transverse colon and colorectum wall electrical stimulation; monitor colon wall bio-impedance and colon manometry in all regions (proximal, transverse and distal) before, during and post stimulation.
217 Files
64.2 GB
57 Records
CC-BY-4.0

Sponsored by

NIH SPARC Program

Yvette Tache updated on July 20, 2023
pre-clinical, autonomic, electroceutical-therapy + More
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Triaxial mechanical testing of dog colon segments

Measurement data related to the mechanical testing of dog colon samples under triaxial (inflation, extension, torsion) loading.
107 Files
7.1 MB
36 Records
CC-BY-4.0

Sponsored by

NIH SPARC Program

Bhavesh Patel updated on July 20, 2023
inflation, force, pressure + More
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Closed-loop modeling of central and intrinsic cardiac nervous system circuits underlying cardiovascular control

Data and plotting code to produce figures and tables published in the manuscript (https://doi.org/10.1002/aic.18033)
79 Files
633.92 MB
No Records
CC-BY-4.0
Raj Vadigepalli updated on July 19, 2023
baroreflex, vagus nerve stimulation, intrinsic cardiac nervous system
Dataset Banner Image

Seizure severity score

Data for "The seizure severity score: a quantitative tool for comparing seizures and their response to therapy" EEG and metadata. Uploaded by Akash Ranjan Pattnaik on 07/15/2023.
1,576 Files
53.25 GB
No Records
ODC-BY
Akash Pattnaik updated on July 18, 2023
intracranial eeg, seizure, epilepsy
Dataset Banner Image

BIOS Health Vagus Nerve Stimulation Calibrator

A tool to target nerve fibre responses to VNS and combine data across pre-clinical cohorts to enhance the tool’s efficiency during intra-operative use in neuromodulation studies
10 Files
34.18 KB
No Records
MIT
Elisabetta Iavarone updated on July 13, 2023
vagus nerve, evoked compounds action potential, gaussian process + More
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Validated computational models predict vagus nerve stimulation thresholds in preclinical animals and humans

Validated computational models of rat (Micro-Leads Neuro, n=1), pig (LivaNova, n=20), and human (LivaNova, n=9) vagus nerve stimulation, built with ASCENT v1.1.1, using histology to define nerve morphologies, and using the cuff electrodes and waveforms
25,950 Files
2.51 GB
No Records
CC-BY-4.0
Nicole Pelot updated on July 17, 2023
vagus nerve stimulation, computational modeling, humans + More
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