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Excitation properties of computational models of unmyelinated peripheral axons

Data and plotting code for excitation responses of multiple single compartment and multi-compartment models of peripheral unmyelinated axons
1,971 Files
954.34 MB
15 Records
CC-BY-4.0

Sponsored by

NIH SPARC Program

Nicole Pelot updated on February 26, 2024
autonomic nervous system, voltage-gated ion channels, vagus nerve + More
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Intravenously injected AAV9 transduced interstitial cells of Cajal in mouse colon

AAV9-c-Kit mouse colon
453 Files
8.03 GB
No Records
CC-BY-4.0
Lixin Wang updated on February 20, 2024
interstitial cells of cajal, enteric nervous system, aav9 + More
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Calcitonin gene-related peptide - immunoreactive (CGRP-IR) axon innervation of mouse stomach

Immunohistochemistry revealed the morphology and distribution of nociceptor Calcitonin gene-related peptide (CGRP) immunoreactive in the muscular layers (longitudinal muscle, myenteric plexus, and circular muscle) of the mouse stomach.
80 Files
2.86 GB
41 Records
CC-BY-4.0
Duyen Nguyen updated on February 14, 2024
mouse, confocal microscopy, cgrp + More
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Mapping of vagal sensory nerve populations and their brainstem projections in mice

This dataset contains confocal images of vagal ganglia and brainstem from TRPV1, Tac1, Pirt and 5HT3 Cre mice crossed with a reporter strain.
4,816 Files
8.34 GB
89 Records
ODC-ODbl
Thomas Taylor-Clark updated on February 14, 2024
medulla, pa5, nts + More
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Influence of vagus nerve stimulation on vagal and cardiac activity in freely moving pigs

This dataset maps the relationship between vagus nerve stimulation (VNS) parameters to their immediate neural and cardiac effects in 2 freely moving pigs.
24 Files
1.49 GB
8 Records
CC-BY-4.0
Oliver Armitage updated on February 14, 2024
evoked compound action potential, stimulation parameters, pig + More
Omkar Athavale updated on February 13, 2024
mathematical model, electrical field stimulation, slow waves + More
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Targeting bladder function with network-specific epidural stimulation after chronic spinal cord injury

This dataset contains measurements of the motor outcomes of the lower urinary tract in response to spinal cord epidural stimulation, utilizing electromyography of the external urinary sphincter and urodynamics.
43 Files
318.25 MB
No Records
CC-BY-4.0
Daniel Medina Aguinaga updated on February 13, 2024
bladder, spinal cord
Dataset Banner Image

Effects of manipulating epithelial cell-nerve signaling on anxiety-like behavior in mice

Elevated-plus maze data collected from animals with silenced/activated gut enterochromaffin cells
21 Files
194.6 KB
81 Records
CC-BY-4.0
Archana Venkataraman updated on February 9, 2024
mouse, mucosal afferents, elevated plus maze + More
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Electromyogram recordings in mice during vagus nerve stimulation

Acute physiological data describing muscle activation during VNS at different burst patterns and frequencies. This includes raw EMG files and quantified outcomes.
2,214 Files
22.89 GB
13 Records
CC-BY-4.0
Nicole Pelot updated on February 8, 2024
vagus, emg, heart rate + More
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Electrocardiogram recordings in mice during vagus nerve stimulation

Acute physiological data describing heart rate modulation during VNS at different burst patterns and frequencies. this includes raw ECG files and quantified outcomes.
2,238 Files
23.15 GB
13 Records
CC-BY-4.0
Nicole Pelot updated on February 8, 2024
vagus nerve, electrophysiology, dynamic range + More
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Two-Color Diffuse In Vivo Flow Cytometer

Processed diffuse in vivo flow cytometry (DiFC) data for the validation of Two-Color DiFC. Including in vitro phantom data and mouse data.
18 Files
62.16 MB
No Records
CDLA-Permissive-1.0
Amber Williams updated on February 6, 2024
circulating tumor cells, metastasis, in vivo flow cytometry + More
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Distribution and morphology of calcitonin gene-related peptide (CGRP) innervation in flat mounts of whole rat atria and ventricles

The sensory (nociceptive) innervation of the whole rat heart (including the atria and ventricles) was immunohistochemically labeled for CGRP. Moreover, high-quality images of the whole tissue were acquired at the single-cell/axon/varicosity resolution.
735 Files
536.29 GB
No Records
CC-BY-4.0
Kohlton Bendowski updated on January 13, 2024
calcitonin gene-related peptide, whole heart, vasculature + More
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Sex differences in sympathetic gene expression and cardiac neurochemistry in Wistar Kyoto rats

Characterizes the transcriptome of both male and female stellate ganglia and to correlate that with catecholamine and acetylcholine content in the heart.
43 Files
29.94 MB
13 Records
CC-BY-4.0
Jeffrey Ardell updated on January 12, 2024
sparc, transcriptome, sympathetic + More
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Quantitation of nodose neurons labelled by retrograde tracing from selective gastric mucosal and gastric muscle injection

Microinjection of fluorescent nanospheres into either the muscle or mucosal of the stomach in the corpus regions in rats labels distinct populations of nodose neurons
135 Files
62 GB
77 Records
CC-BY-4.0
Martin Stebbing updated on January 11, 2024
nodose, muscle, rat + More
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RNAseq analysis of nodose neurons projecting to specific regions and tissue layers within the rat stomach

Vagal sensory neurons projecting to either the muscle or mucosal layers of the rat stomach in the fundus, corpus or antrum were identified using localized microinjections retrograde tracer, before being isolated and characterized using RNAseq.
1,275 Files
81.85 GB
No Records
CDLA-Sharing-1.0
Martin Stebbing updated on January 11, 2024
rat, nodose, rnaseq + More
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Quantitation of nodose neurons labelled by retrograde tracing from selective injections into the gastric mucosa or muscle in the antrum and fundus

Microinjections of a non-diffusible retrograde tracer were made into the muscle layer or the mucosal layer of the rat stomach in either the antrum or the fundus region. Retrogradely labelled nodose neurons were studied using 3-D confocal microscopy.
211 Files
52.44 GB
No Records
CC-BY-4.0
Martin Stebbing updated on January 11, 2024
antrum, fundus, stomach + More
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Synaptic components function and modulation characterized by GCaMP6f calcium imaging in cholinergic myenteric ganglion neurons

Synapses and their components on myenteric neurons assessed by GCaMP Ca2+ imaging
204 Files
365.55 GB
199 Records
CDLA-Permissive-1.0
Marthe Howard updated on January 11, 2024
myenteric, nicotinic, synapse + More
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Quantification of thickness of the gastric muscle in the rat stomach

This dataset contains images and analysis used to quantify the thickness of the mucosal and muscle layers of the rat stomach and to determine muscle orientations and relationships.
644 Files
12.52 GB
No Records
CC-BY-4.0
Martin Stebbing updated on January 11, 2024
corpus, fundus, antrum + More
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Morphologies dimensions and targets of gastric nitric oxide synthase neurons in the rat stomach

This dataset contains images and analysis used to quantify the distributions and targets of neuronal nitric oxide synthase (nNOS) immunoreactive neurons in the rat stomach.
1,834 Files
144.2 GB
110 Records
CC-BY-4.0
Martin Stebbing updated on January 11, 2024
gastric motor neurons, stomach, rat + More
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ASCENT Tutorial

ASCENT tutorial example on o²S²PARC
12 Files
99.98 KB
No Records
GPL-3.0
Elisabetta Iavarone updated on December 28, 2023
vagus nerve stimulation, peripheral nerve stimulation, neural engineering + More
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ASCENT Guided Mode Demo

Demo of the ASCENT pipeline on o²S²PARC, with a limited set of user-defined parameters
13 Files
107.07 KB
No Records
GPL-3.0
Elisabetta Iavarone updated on December 28, 2023
vagus nerve stimulation, peripheral nerve stimulation, neural engineering + More
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ASCENT Base

ASCENT software on o²S²PARC
12 Files
99.66 KB
No Records
GPL-3.0
Elisabetta Iavarone updated on December 28, 2023
peripheral nerve stimulation, neural engineering, computational modelling + More
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Chronic intermittent hypoxia remodels catecholaminergic innervation in mouse atria

Mapping the remodeling of tyrosine hydroxylase labeled axons in the flat-mount of whole left and right atria
178 Files
21.75 GB
No Records
CC-BY-4.0
Ariege (Gigi) Bizanti updated on December 28, 2023
chronic intermittent hypoxia, sympathetic innervation, heart-brain + More
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Michigan High Res EEG - UMHS0018

Scalp and stereotactic EEG for UMHS0018. Class Ib outcome
30 Files
122.59 GB
1 Record
William Stacey updated on December 18, 2023
eeg, intracranial, sleep + More
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Michigan High Res EEG - UMHS 0028

Scalp, intracranial grid, and standard depth EEG for Michigan Patient 28. Class I outcome
34 Files
455.29 GB
No Records
William Stacey updated on December 18, 2023
eeg, intracranial, high resolution
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