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Evaluation of bilateral gastric electrical stimulation to improve energy balance regulation in female Sprague-Dawley rats consuming a 45% high-fat diet

Microstructural analysis of food intake as a behavioral endpoint to determine the effect of bilateral electrical stimulation of the forestomach on the consumption of a 45% high fat diet by female Sprague-Dawley rats.
48 Files
3.52 MB
No Records
CC-BY-4.0
Robert Phillips updated on July 12, 2024
rat, stomach, vagus nerve + More
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Neurochemical anatomy of porcine right atrial ganglionated plexus and sinoatrial node

This dataset contains results from IHC analyses of RAGP and nerves in the SAN and right atrium of pig hearts. Neurochemical phenotypes of neurons and nerves were evaluated, and RAGP neurons that innervate the SAN were identified by retrograde labeling.
4,892 Files
9.73 GB
103 Records
CC-BY-4.0
Donald Hoover updated on July 9, 2024
neurophil, nitrergic, porcine + More
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A novel compartmental modeling approach to simulate stomach motility and gastric emptying

A model to simulate gastric emptying and stomach motility for a healthy human stomach
16 Files
398.8 KB
No Records
MIT
Shannon Fernandes updated on July 9, 2024
g, gastric emptying, stomach motility + More
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Generic human stomach scaffold

Annotated human stomach scaffold available for registration of segmented neural anatomical-functional mapping of enteric neural circuits.
54 Files
215.5 MB
13 Records
CC-BY-4.0

Sponsored by

NIH SPARC Program

Mabelle Lin updated on July 9, 2024
stomach, myenteric plexus, human
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Computational analysis of the human sinus node action potential - Model development and effects of mutations

CellML version of the Fabbri et al. 2017 mathematical model of the spontaneous electrical activity of a human sinoatrial node (SAN) pacemaker cell
19 Files
167.28 KB
13 Records
CC-BY-4.0

Sponsored by

NIH SPARC Program

Alan Garny updated on July 9, 2024
ion channels, cardiovascular models, sinoatrial node + More
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Fabbri-based composite SAN model

CellML version of the Fabbri et al. 2017 human sinoatrial node (SAN) cell model and an ODE-based version of the Gerstner & Kistler 2002 brain stem model combined to demonstrate the effect of brain stem activity on heart rate
19 Files
174.48 KB
14 Records
CC-BY-4.0

Sponsored by

NIH SPARC Program

Alan Garny updated on July 3, 2024
ion channels, cardiovascular models, sinoatrial node + More
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Simulation of the short term impact of atrial fibrillation on hemodynamic variables

The computational model of the human cardio-baroreflex provides a simulation of four variables (heart rate, mean arterial pressure, stroke volume and left atrial end systolic volume) following an onset of atrial fibrillation.
15 Files
528.85 KB
No Records
GPL-3.0
Oluwasanmi Adeodu updated on July 1, 2024
atrial fibrillation, cardiac system, baroreflex + More
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Selective recording of physiologically evoked neural activity in a mixed autonomic nerve using a minimally invasive array

This data set includes recording and analysis of extracted signals form the pelvic nerve during cystometry testing in anesthetized rats.
867 Files
20.38 GB
No Records
CC-BY-4.0
Janet Keast updated on June 28, 2024
peripheral nerve recording, electrophysiology, pelvic nerve + More
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Excitation properties of computational models of unmyelinated peripheral axons

Data and plotting code for excitation responses of multiple single compartment and multi-compartment models of peripheral unmyelinated axons
1,974 Files
960.73 MB
15 Records
CC-BY-4.0

Sponsored by

NIH SPARC Program

Nicole Pelot updated on June 12, 2024
autonomic nervous system, voltage-gated ion channels, vagus nerve + More
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A 3D human whole-body model with integrated organs vasculature musculoskeletal and nervous systems for mapping nerves

The generated body scaffold was fitted to data, and the organ fiducial markers were embedded in the human whole-body. The landmarks were obtained from image data and also were defined in the body scaffold. Furthermore, nerve centrelines are added.
5,575 Files
220.38 MB
3 Records
CC-BY-4.0
Mabelle Lin updated on June 1, 2024
musculoskeletal system, vasculature system, nervous system + More
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Targeting bladder function with network-specific epidural stimulation after chronic spinal cord injury

This dataset contains measurements of the motor outcomes of the lower urinary tract in response to spinal cord epidural stimulation, utilizing electromyography of the external urinary sphincter and urodynamics.
48 Files
341.26 MB
No Records
CC-BY-4.0
Daniel Medina Aguinaga updated on April 19, 2024
bladder, spinal cord
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Long read sequencing of human dorsal root ganglia

Long read sequencing was used to identify and characterize the isoforms expressed in the human dorsal root ganglion (hDRG). PacBio IsoSeq circular consensus sequencing was used on 3 hDRGs from 3 human organ donors.
22 Files
159.27 MB
No Records
CC-BY-4.0
Asta Arendt-Tranholm updated on April 6, 2024
long read sequencing, human, drg
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Transcriptomic and neurochemical analysis of the stellate ganglia in mice highlights sex differences

This dataset contains baseline measurements of mouse stellate ganglia using RNAseq
38 Files
28.89 MB
44 Records
CC-BY-4.0

Sponsored by

NIH SPARC Program

Jeffrey Ardell updated on March 19, 2024
sympathetic, transcriptome, neurotransmitters + More
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Quantification of enteric ganglia in the three main regions of the rat stomach

This dataset contains images and analysis used to quantify the number of neurons per ganglia, size and density of myenteric and submucosal ganglia in the rat gastric fundus, corpus and antrum.
612 Files
445.24 GB
56 Records
CC-BY-4.0
Martin Stebbing updated on March 19, 2024
rat, ganglia, antrum + More
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Vagal preganglionic axons arborize in myenteric plexus into two patterns generating nitrergic and non-nitrergic postganglionic motor units

The dataset consists of photomicrographs of the individual ganglia traversed by each of 54 vagal preganglionic fibers that had previously been fully traced using Neurolucida software.
2,566 Files
21.45 GB
103 Records
CC-BY-4.0
Deborah Jaffey updated on March 18, 2024
preganglionic, nitrergic, efferent + More
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Vasculature in mouse colon and relationship with enteric nervous system glia and macrophages

This dataset contains microscopic images examining vascular structures in the mouse colon, yielding 3D images.
1,690 Files
88.5 GB
No Records
CC-BY-4.0
Lixin Wang updated on March 18, 2024
vessels, microvessels, capillaries + More
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Light microscopic analysis of synaptic input to neurons in the rat major pelvic ganglion

High resolution 3D confocal images of autonomic neurons and closely opposing synaptic boutons were segmented and analysed to obtain statistics on preganglionic input to immunohistochemically classified lower urinary tract projecting MPG neurons.
6,264 Files
2.76 TB
6,528 Records
CC-BY-4.0
Janet Keast updated on March 18, 2024
synapse, 3d image analysis, autonomic ganglion + More
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Transduction of systemically administered adeno-associated virus in the colonic enteric nervous system of adult mice

This dataset contains photomicrographs of the systemic AAV mouse colon enteric nervous system (ENS) that were acquired using confocal microscopes, visualized in three dimensions, and digitally segmented.
2,630 Files
93.5 GB
No Records
CC-BY-4.0
Lixin Wang updated on March 18, 2024
enteric nervous system, distribution, adeno-associated virus + More
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Substance P-immunoreactive axons in the antrum-pylorus-duodenum of mice

Immunohistochemistry revealed the morphology and distribution of nociceptor substance P-immunoreactive (SP-IR) axons and terminals in the muscular, submucosal, and mucosal layers of the antrum, pylorus, and duodenum regions of the mice.
380 Files
70.98 GB
22 Records
CC-BY-4.0
Duyen Nguyen updated on March 18, 2024
substance p, nociceptive afferent, muscles + More
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Intravenously injected AAV9 transduced interstitial cells of Cajal in mouse colon

AAV9-c-Kit mouse colon
461 Files
8.03 GB
No Records
CC-BY-4.0
Lixin Wang updated on March 20, 2024
interstitial cells of cajal, enteric nervous system, aav9 + More
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Calcitonin gene-related peptide - immunoreactive (CGRP-IR) axon innervation of mouse stomach

Immunohistochemistry revealed the morphology and distribution of nociceptor Calcitonin gene-related peptide (CGRP) immunoreactive in the muscular layers (longitudinal muscle, myenteric plexus, and circular muscle) of the mouse stomach.
80 Files
2.86 GB
41 Records
CC-BY-4.0
Duyen Nguyen updated on February 14, 2024
mouse, confocal microscopy, cgrp + More
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Mapping of vagal sensory nerve populations and their brainstem projections in mice

This dataset contains confocal images of vagal ganglia and brainstem from TRPV1, Tac1, Pirt and 5HT3 Cre mice crossed with a reporter strain.
4,816 Files
8.34 GB
89 Records
ODC-ODbl
Thomas Taylor-Clark updated on February 14, 2024
medulla, pa5, nts + More
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Influence of vagus nerve stimulation on vagal and cardiac activity in freely moving pigs

This dataset maps the relationship between vagus nerve stimulation (VNS) parameters to their immediate neural and cardiac effects in 2 freely moving pigs.
24 Files
1.49 GB
8 Records
CC-BY-4.0
Oliver Armitage updated on February 14, 2024
evoked compound action potential, stimulation parameters, pig + More
Omkar Athavale updated on February 13, 2024
mathematical model, electrical field stimulation, slow waves + More
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Effects of manipulating epithelial cell-nerve signaling on anxiety-like behavior in mice

Elevated-plus maze data collected from animals with silenced/activated gut enterochromaffin cells
21 Files
194.6 KB
81 Records
CC-BY-4.0
Archana Venkataraman updated on February 9, 2024
mouse, mucosal afferents, elevated plus maze + More
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