Microstructural analysis of food intake as a behavioral endpoint to determine the efficacy of properly placed, optimally tuned gastric electrodes.
Study Purpose: Bioelectric modulation of the vagal innervation of the stomach has had only limited success as a prescription for modifying ingestive behavior because electrodes were often implanted without adequate knowledge of the underlying vagus-stomach neural circuitry, and stimulation parameters were used without information as to the stimulus-response relationships. Therefore, we used microstructural analysis of food intake as a behavioral endpoint to determine the efficacy of properly placed, optimally tuned gastric electrodes.
Data Collection: The dataset includes 5 .tab files and one .dat file in the source folder (approx. 12 MB), two .xlsx spreadsheets in the primary folder (177 KB), and three .xlsx spreadsheets in the derivative folder (81 KB) detailing the feeding pattern of the 23 subjects.
Primary Conclusion: None stated.
Curator's Notes
Experimental Design: Based on high-resolution maps of vagal terminal specializations, patch electrodes on the muscle wall of the stomach of 18 healthy adult male Sprague-Dawley rats were implanted. An additional five rats served as un-operated controls. Following recovery, the feeding behavior of individual rats was continuously monitored (BioDAQ automated intake monitoring system) while being stimulated for 42 days using pulse parameters known to increase the number of gastric contractions (0.6mA, 0.2ms, 5Hz, 20s On:40s Off for 21 days, followed by 1.0mA, 0.2ms, 5Hz, 20s On:40s Off for an additional 21 days).
Completeness: This dataset is complete.
Subjects & Samples: Adult male (n=23) Sprague-Dawley (RRID:RGD_737903) were used in this study.
Primary vs derivative data: Within pool-1 are the perf-1 and perf-2 folders containing, respectively, the primary data for individual subjects for Experiment 1 and Experiment 2 in multi spreadsheet XLSX format.
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