On-Demand Seizures Facilitate Rapid Screening of Therapeutics for Epilepsy

Hajime Takano, Ph.D.

Flavia Vitale, Ph.D.

Optogenetically Induced Seizures for Rapid Epilepsy Therapy Screening.

Updated on September 6, 2025 (Version 1)

Corresponding Contributor:

Hajime Takano

79 Files

3.94 GB

No Records

CC-0-1.0

Dataset Overview

This is data from an on-demand seizure study conducted in the Takano Lab at the Children’s Hospital of Philadelphia / University of Pennsylvania. We demonstrated that optogenetically induced seizures in the IHK epilepsy mouse model (intrahippocampal kainic acid injection model) can be used as a platform for screening anti-seizure medications (ASMs).

reference: Yuzhang Chen, Brian Litt, Flavia Vitale,Hajime Takano (2024) On-Demand Seizures Facilitate Rapid Screening of Therapeutics for Epilepsy eLife 13:RP101859 https://doi.org/10.7554/eLife.101859.2

The data include information on the animals (Excel spreadsheet), details of all seizures (spontaneous and induced, Excel spreadsheet), and EEG traces (4 channels: 2 hippocampal and 2 cortical) in .mat file format, and graphs (Graphpad Prism version9).

Files

Root Directory

1 - 0 of 0 files

No files found.

About this dataset

Publishing history

September 6, 2025

Originally Published

September 6, 2025 (Version 1)

Last Updated

DOI

https://doi.org/10.26275/4uue-pck4

Cite this dataset

Takano, H., & Vitale, F. (2025). On-Demand Seizures Facilitate Rapid Screening of Therapeutics for Epilepsy (Version 1) [Data set]. Pennsieve Discover. https://doi.org/10.26275/4UUE-PCK4

Formatted as: | | | More on Crosscite.org

References

Describes

Chen, Y., Litt, B., Vitale, F., & Takano, H. (2025). On-Demand Seizures Facilitate Rapid Screening of Therapeutics for Epilepsy. CLOCKSS. https://doi.org/10.7554/elife.101859.2