Demo of the ASCENT pipeline on o²S²PARC, with a limited set of user-defined parameters
Study Purpose: To provide a simplified, ready-to-use installation of the ASCENT pipeline with a graphical interface where users can select parameter values from drop-down menus to simulate biophysical responses to vagus nerve stimulation. For more information about ASCENT, see the ASCENT paper, code repository, and documentation.
Data Collection: Not applicable; this is a computational dataset. The simulations were performed with ASCENT v.1.2.1
Primary Conclusion: Modeled activation threshold computed in this o²S²PARC implementation match the results computed with the ASCENT code. In addition, users do not need to perform any installation and are guided through the implementation.
Curator's Notes
Experimental Design: Not applicable; this is a computational dataset.
Completeness: This dataset is part of a larger study, "ASCENT on o²S²PARC"
Subjects & Samples: This is a computational model dataset; thus no subjects are described.
Primary vs derivative data: Not applicable. This is a computational study. Only a configuration file to view and run the simulation on the oSPARC platform is provided.
Code Availability: A code repository for this dataset is available here, see documentation for details.
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Musselman, E. D., Cariello, J. E., Grill, W. M., & Pelot, N. A. (2021). ASCENT (Automated Simulations to Characterize Electrical Nerve Thresholds): A pipeline for sample-specific computational modeling of electrical stimulation of peripheral nerves. PLOS Computational Biology, 17(9), e1009285. https://doi.org/10.1371/journal.pcbi.1009285