Histology-based computational models of implanted human cervical vagus nerve stimulation with the LivaNova helical cuff electrode

Study Purpose: To implement, simulate, and analyze computational models of human vagus nerve stimulation with the LivaNova helical cuff to study the effects of fascicle size on fiber activation thresholds

Data Collection: We used ASCENT v1.1.1 to build 3D computational models of nine human vagus nerves instrumented with the LivaNova helical cuff electrode. We simulated activation thresholds for 10 um myelinated fibers in response to a 0.5 ms/phase biphasic rectangular pulse.

Primary Conclusion: Fibers in larger diameter fascicles have higher activation thresholds than fibers in smaller diameter fascicles.

Curator's Notes

Experimental Design: Histology-based computational models of vagus nerve stimulation in humans with the LivaNova helical cuff electrode.

Completeness: This dataset is complete.

Subjects & Samples: Only virtual subjects were used in this study, which are based on previously published histology from embalmed human cadavers.

Primary vs derivative data: Not applicable. This is a computational study. The files in primary/sub-*/sam-*-sub-*/samples/*/ are ASCENT input configuration files (i.e., sample.json, models/*/model.json) and outputs (i.e., individual fiber activation thresholds models/*/sims/*/n_sims/*/data/outputs/thresh_inner*_fiber*.dat). Additionally, the files in primary/sub-*/sam-*-sub-*/samples/*/ contain key intermediate files created by ASCENT, including the extracellular potentials applied to the fiber models (models/*/sims/*/n_sims/*/data/inputs/inner*_fiber*.dat) and the stimulation waveform (models/*/sims/*/n_sims/*/data/inputs/waveform.dat).

Code Availability: Run the plotting scripts in the dataset in files/code/ using Python 3.7. The data were generated using ASCENT v1.1.1 (repository; documentation): see README.txt for details.