Computational model of heart rate modulation in mice during vagus nerve stimulation

Study Purpose: The study purpose was to construct a computational model of parasympathetic innervation of the sinoatrial node in mice to investigate the effects of vagus nerve stimulation.

Data Collection: We simulated network activity and quantified heart rate modulation during vagus nerve stimulation.

Primary Conclusion: The model reproduced the effects of vagus nerve stimulation across stimulation amplitude, frequencies, and burst patterns.

Curator's Notes

Experimental Design: A computational model of parasympathetic innervation of the sinoatrial node in mice.

Completeness: This dataset is complete.

Subjects & Samples: This is a computational model dataset; thus no subjects are described.

Primary vs derivative data: Not applicable. This is a computational study; the primary data folder contains MATLAB simulations of vagus nerve stimulation across stimulation amplitude, frequencies, and burst patterns. Outcome files are saved as .mat structures and sorted as "runs" (repeats).

Code Availability: Matlab script in the code folder requires python with NEURON https://www.neuron.yale.edu/neuron/download. See the accompanying manuscript and README.txt for details.