Computational models of monopolar pig vagus nerve stimulation with a six-contact cuff, built with ASCENT v1.0.1, using the histology for six pigs in which electrophysiological outputs were recorded in vivo.
Study Purpose: To implement, simulate, and analyze computational models of pig vagus nerve stimulation (VNS) with the six-contact ImThera cuff electrode using nerve morphology and cuff placement that correspond to animal-specific experiments.
Data Collection: We used ASCENT v1.0.1 to build a 3D model of six pig vagus nerves instrumented with a six-contact cuff electrode. We simulated monopolar thresholds for 3 um “B” and 13 um “A alpha” fibers, which we compared to heart rate and laryngeal electromyogram (EMG) in vivo responses, respectively.
Primary Conclusion: Currents sufficient to activate B fibers also robustly activated A alpha fibers. Models accurately predicted A alpha onset thresholds, A alpha saturation thresholds, and B onset thresholds, but underestimated B saturation thresholds.
Experimental Design: This is a computational study.
Completeness: This dataset is complete.
Subjects & Samples: Only virtual subjects were used in this study. We modeled six right cervical pig vagus nerves. Histology and experimental data obtained from miniature swine subjects originate from https://doi.org/10.26275/efbj-8evl.
Primary vs derivative data: Primary data folder contains three data elements.
Nerve morphology: The files in
primary/sub-*/sam-*-sub-*/samples/*/slides/0/0/masks/ are the histology and segmentations of the vagus nerve morphology at the site of stimulation for this specific subject/sample. The data are also published in the associated: https://doi.org/10.26275/efbj-8evl.
Model inputs and outputs: The files in
primary/sub-*/sam-*-sub-*/samples/*/ are ASCENT input configuration files (i.e., sample.json,
models/*/model.json) and outputs (i.e., individual fiber activation thresholds
Additionally, the files in
primary/sub-*/sam-*-sub-*/samples/*/ contain key intermediate files created by ASCENT, including the extracellular potentials applied to the fiber models (
models/*/sims/*/n_sims/*/data/inputs/inner*_fiber*.dat) and the stimulation waveform (
In vivo recordings for model validation: The files in
primary/sub-*/sam-*-sub-*/samples/*/ephys/ contain electrophysiological recordings (i.e., EMG, EKG) in response to vagus nerve stimulation for this specific subject/sample combination. The data are also published in the associated: https://doi.org/10.26275/efbj-8evl.
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