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Sympathetic nerve stimulation of mouse and rabbit hearts

Crystal Ripplinger
,
Eleonora Grandi
,
Lianguo Wang
,
Stefano Morotti

We combined experiments and computational modeling to investigate the effects of sympathetic nerve stimulation on mouse and rabbit hearts.

Updated on January 5, 2022 (Version 1)

Corresponding Contributor:

Stefano Morotti
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Dataset Overview

Study Purpose: We performed physiological sympathetic nerve stimulation while optically mapping cardiac action potentials and intracellular calcium transients in innervated mouse and rabbit hearts.

Data Collected: This package includes experimental optical mapping data (derived from https://doi.org/10.1113/JP278016) and mathematical models of mouse and rabbit ventricular myocytes.

Primary Conclusion: We found notable differences in spatio-temporal repolarization dynamics, and used species-specific computational models to investigate the underlying mechanisms.


Curator's Notes

Experimental Design: A computation model. Experimental data derived from https://doi.org/10.1113/JP278016

Completeness: This dataset is complete.

Subjects & Samples: N/A (computational modeling dataset)

Primary vs derivative data: There is no primary data, only a derivative folder containing experimental optical mapping data summarized in the multi spreadsheet excel table.

Code Availability Matlab codes (and instructions) for simulating the model of mouse and rabit ventricular myocytealong with simulations are contained in the code folder. Each code folder contains detailed instructions on how to use the code and reproduce simulations. Model codes are also available for download at: https://somapp.ucdmc.ucdavis.edu/Pharmacology/bers/, or http://elegrandi.wixsite.com/grandilab/downloads.

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Publishing history

January 5, 2022
Originally Published
January 5, 2022 (Version 1)
Last Updated

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