Acute effects of gastric electrical stimulation settings on gastric motility assessed with magnetic resonance imaging in rats

Study Purpose: This study aims to evaluate the effects of gastric electrical stimulation, GES, settings on gastric motility in rats.

Data Collection: A multi‐slice MRI sequence was used to scan antral contractions with high spatial and temporal resolution. The configuration of vagus nerve stimulation, VNS, was varied in terms of pulse parameters (amplitude, width, and frequency).

Primary Conclusion: none stated

Curator's Notes

Experimental Design: Male rats, ranging from 272 to 306g body weight, were used in this study. All animals underwent abdominal surgery for implantation of a patch electrode on the forestomach. The animals were allowed at least 1 week for post-surgical recovery. A gadolinium‐based contrast agent was mixed with the animal’s meal in order for chyme to appear “bright” in MRI scans, thereby delineating the gastric and intestinal volume. A multi‐slice MRI sequence was used to scan gastrointestinal (GI) functions and physiology with high spatial and temporal resolution.

Completeness: This is a part of a larger study: Effects of Vagus Nerve Stimulation/Gastric Electrical Stimulation on Gastric Emptying and Motility Assessed with Magnetic Resonance Imaging

Subjects & Samples: This study used adult Sprague-Dawley (RRID:RGD_70508) male rats (n=4) between 6-11 weeks old.

Primary vs derivative data: Primary data is organized by the subject ID. Each subject folder contains 3D+ time motility MRI data before onset and during various vagus nerve stimulation (VNS) parameters. Derivered data consists of segmentation of antrum and antral motility maps for each of the experimental subjects.