We are testing the hypothesis that activation of phrenic afferent neurons modulates contralateral phrenic motor output and blood pressure in the adult rat.
Study Purpose: To test the hypothesis that activation of phrenic afferent neurons modulates contralateral phrenic motor output and blood pressure in the adult rat.
Data Collection: This data set describes the impact of phrenic nerve stimulation on efferent phrenic nerve bursting in the rat. By stimulating the phrenic nerve, afferent neurons (i.e., diaphragm sensory "phrenic afferents") were activated, and the results describe the impact on phrenic motor output in spinal-intact rats and rats with spinal cord injury.
Primary Conclusion: None stated
Experimental Design: Adult rats were used for this study. Recordings of inspiratory triggered phrenic nerve stimulation that was delivered for 20 seconds (approximately 18 breaths) at 40pps. They were allocated to 4 experimental groups based on pulse width to target activation: (1) narrow pulse, (2) wide pulse, (3) time controls, and (4) dorsal rhizotomy.
Completeness: This study is complete.
Subjects & Samples: Male (n=20) and female(n=20) adult rats (RRID:RGD_8547938) were used for this study, ages 12 - 18 weeks old.
Primary vs derivative data: The primary folders consist of folders divided by subject identification. This folder contains Spike2 formatted (smrx) files. There is no derivative data for this study.
Important Notes: This study has a docs folder that contains a pdf copy of surgery notes for each subject.
Code Availability: Not applicable
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